Searchable abstracts of presentations at key conferences in endocrinology

ea0098b19 | Basic Science | NANETS2023

Label-free phenotyping of duodenal neuroendocrine tumors using tissue autofluorescence microscopy and digital spatial profiling

Knapp Thomas , Duan Suzann , Merchant Juanita , Sawyer Travis

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are an extremely heterogenous group of diseases with complicated treatment and management decisions. For example, patients with Multiple Endocrine Neoplasia Type 1 (MEN1)-associated gastrinomas present with more aggressive tumors and poorer outcomes. Recent work has shown that sequencing (transcriptomic, proteomic) can phenotype GEP-NETs to accurately reflect important clinical parameters such as tumor aggress...